Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of gene...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J Ratcliffe, David R Mole, Johannes Schödel
Format: Artykuł
Język:English
Wydane: Public Library of Science (PLoS) 2017-07-01
Seria:PLoS Genetics
Dostęp online:http://europepmc.org/articles/PMC5536434?pdf=render

Internet

http://europepmc.org/articles/PMC5536434?pdf=render

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