Preparation and Characterization of Fenofibrate Microparticles with Surface-Active Additives: Application of a Supercritical Fluid-Assisted Spray-Drying Process

Preparation and Characterization of Fenofibrate Microparticles with Surface-Active Additives: Application of a Supercritical Fluid-Assisted Spray-Drying Process

In this study, supercritical fluid-assisted spray-drying (SA-SD) was applied to achieve the micronization of fenofibrate particles possessing surface-active additives, such as d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), sucrose mono palmitate (Sucroester 15), and polyoxyethylene 52 ste...

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Bibliographic Details
Main Authors: Jeong-Soo Kim, Heejun Park, Eun-Sol Ha, Kyu-Tae Kang, Min-Soo Kim, Sung-Joo Hwang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
supercritical fluid assisted spray-drying (SA-SD)
fenofibrate
surface-active additive
spray-drying (SD)
microparticle
biopharmaceutical performance
Online Access:https://www.mdpi.com/1999-4923/13/12/2061

Internet

https://www.mdpi.com/1999-4923/13/12/2061

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