Genetic Variants in the 3’UTR of <i>BRCA1</i> and <i>BRCA2</i> Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Genetic Variants in the 3’UTR of <i>BRCA1</i> and <i>BRCA2</i> Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer (HBOC) syndrome is mainly caused by mutations in the <i>BRCA1</i> and <i>BRCA2</i> genes. The 3’UTR region allows for the binding of microRNAs, which are involved in genetic tune regulation. We aimed to identify allelic variants on 3’UTR m...

Full description

Bibliographic Details
Main Authors: María Marisela Sánchez-Chaparro, Idalia Garza-Veloz, Omar Alejandro Zayas-Villanueva, Margarita L. Martinez-Fierro, Iván Delgado-Enciso, Mayra Alejandra Gomez-Govea, Laura Elia Martínez-de-Villarreal, Diana Reséndez-Pérez, Iram Pablo Rodríguez-Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Diagnostics
Subjects:
hereditary breast and ovarian cancer
<i>BRCA1</i>
<i>BRCA2</i>
miRNA
polymorphism
3’UTR region
Online Access:https://www.mdpi.com/2075-4418/10/5/298

Internet

https://www.mdpi.com/2075-4418/10/5/298

Similar Items