Genetic Variants in the 3’UTR of <i>BRCA1</i> and <i>BRCA2</i> Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Genetic Variants in the 3’UTR of <i>BRCA1</i> and <i>BRCA2</i> Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer (HBOC) syndrome is mainly caused by mutations in the <i>BRCA1</i> and <i>BRCA2</i> genes. The 3’UTR region allows for the binding of microRNAs, which are involved in genetic tune regulation. We aimed to identify allelic variants on 3’UTR m...

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Bibliographic Details
Main Authors: María Marisela Sánchez-Chaparro, Idalia Garza-Veloz, Omar Alejandro Zayas-Villanueva, Margarita L. Martinez-Fierro, Iván Delgado-Enciso, Mayra Alejandra Gomez-Govea, Laura Elia Martínez-de-Villarreal, Diana Reséndez-Pérez, Iram Pablo Rodríguez-Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Diagnostics
Subjects:
hereditary breast and ovarian cancer
<i>BRCA1</i>
<i>BRCA2</i>
miRNA
polymorphism
3’UTR region
Online Access:https://www.mdpi.com/2075-4418/10/5/298

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