The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin

The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin

Background: Chemoresistance is a common event after cancer chemotherapy, including gastric cancer (GC). Cisplatin has been reported to induce the DNA damage response (DDR), thus leading to chemoresistance. VE-821, a specific inhibitor of ATR, has been proven to suppress a variety of solid malignanci...

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Bibliographic Details
Main Authors: Haochen Su, Yue Yuan, Jiatong Tang, Yixuan Zhang, Hao Wu, Yin Zhang, Jiawei Liang, Lei Wang, Xiaoping Zou, Shuling Huang, Shu Zhang, Ying Lv
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Translational Oncology
Subjects:
ATR inhibitor
Cisplatin
Gastric cancer
Chemoresistance
Organoid
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323001298

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http://www.sciencedirect.com/science/article/pii/S1936523323001298

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