A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

Abstract Background Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain antibodies (sdAbs) that can be used to trace CD38+ tum...

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Bibliographic Details
Main Authors: Elodie Duray, Margaux Lejeune, Frederic Baron, Yves Beguin, Nick Devoogdt, Ahmet Krasniqi, Yoline Lauwers, Yong Juan Zhao, Matthias D’Huyvetter, Mireille Dumoulin, Jo Caers
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Hematology & Oncology
Subjects:
Multiple myeloma
CD38
Theranostic
Single-domain antibody
Nanobody
Radio-immunotherapy
Online Access:https://doi.org/10.1186/s13045-021-01171-6

Internet

https://doi.org/10.1186/s13045-021-01171-6

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