Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

Abstract Background Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 alterations have been observed in a subpopulation of pilocytic astrocytom...

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Bibliographic Details
Main Authors: Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo, Kirsi J. Granberg
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Tissue microarray
Deep-sequencing
FGFR inhibition
Immunohistochemistry staining
Online Access:http://link.springer.com/article/10.1186/s12885-017-3274-9

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http://link.springer.com/article/10.1186/s12885-017-3274-9

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