Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.

Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.

<h4>Objective</h4>Oncostatin M (OSM) is produced by activated T cells, monocytes, and dendritic cells and signals through two distinct receptor complexes consisting of gp130 and LIFR (I) or OSMR-β and gp130 (II), respectively. Aim of this study was to analyze the role of OSM in intestina...

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Bibliographic Details
Main Authors: Florian Beigel, Matthias Friedrich, Corina Probst, Karl Sotlar, Burkhard Göke, Julia Diegelmann, Stephan Brand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093498&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093498&type=printable

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