Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

Abstract In age-related neurodegenerative diseases, pathology often develops slowly across the lifespan. As one example, in diseases such as Alzheimer’s, vascular decline is believed to onset decades ahead of symptomology. However, challenges inherent in current microscopic methods make longitudinal...

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Bibliographic Details
Main Authors: Konrad W. Walek, Sabina Stefan, Jang-Hoon Lee, Pooja Puttigampala, Anna H. Kim, Seong Wook Park, Paul J. Marchand, Frederic Lesage, Tao Liu, Yu-Wen Alvin Huang, David A. Boas, Christopher Moore, Jonghwan Lee
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38609-z