In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.

In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.

The hallmark of severe COVID-19 involves systemic cytokine storm and multi-organ injury including testicular inflammation, reduced testosterone, and germ cell depletion. The ACE2 receptor is also expressed in the resident testicular cells, however, SARS-CoV-2 infection and mechanisms of testicular i...

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Bibliographic Details
Main Authors: Stefanos Giannakopoulos, Daniel P Strange, Boonyanudh Jiyarom, Omar Abdelaal, Aaron W Bradshaw, Vivek R Nerurkar, Monika A Ward, Jackson Bakse, Jonathan Yap, Selena Vanapruks, William A Boisvert, Michelle D Tallquist, Cecilia Shikuma, Hooman Sadri-Ardekani, Philip Clapp, Sean V Murphy, Saguna Verma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011409

Internet

https://doi.org/10.1371/journal.ppat.1011409

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