14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming

Summary: Cell fate conversion is associated with extensive post-translational modifications (PTMs) and architectural changes of sub-organelles, yet how these events are interconnected remains unknown. We report here the identification of a phosphorylation code in 14-3-3 binding motifs (PC14-3-3) tha...

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Bibliographic Details
Main Authors: Liu Liu, Ienglam Lei, Shuo Tian, Wenbin Gao, Yijing Guo, Zhaokai Li, Ziad Sabry, Paul Tang, Y. Eugene Chen, Zhong Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003826