Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

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Bibliographic Details
Main Authors: Yongfeng Fan, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Isin N. Geren, Consuelo Garcia-Rodriguez, Theresa J. Smith, Leonard A. Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A. Wilson, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Toxins
Subjects:
botulinum antitoxin
inhibitory antibodies
Botulinum neurotoxin serotype B
alpha-exosite
Online Access:http://www.mdpi.com/2072-6651/7/9/3405

Internet

http://www.mdpi.com/2072-6651/7/9/3405

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