Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

Loss of cellular homeostasis has been implicated in the etiology of several neurodegenerative diseases (NDs). However, the molecular mechanisms that underlie this loss remain poorly understood on a systems level in each case. Here, using a novel computational approach to integrate dimensional RNA-se...

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Bibliographic Details
Main Authors: Lucile Megret, Barbara Gris, Satish Sasidharan Nair, Jasmin Cevost, Mary Wertz, Jeff Aaronson, Jim Rosinski, Thomas F Vogt, Hilary Wilkinson, Myriam Heiman, Christian Neri
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
human
C. elegans
Drosophila
Online Access:https://elifesciences.org/articles/64984

Internet

https://elifesciences.org/articles/64984

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