Nanobiopsy investigation of the subcellular mtDNA heteroplasmy in human tissues
Abstract Mitochondrial function is critical to continued cellular vitality and is an important contributor to a growing number of human diseases. Mitochondrial dysfunction is typically heterogeneous, mediated through the clonal expansion of mitochondrial DNA (mtDNA) variants in a subset of cells in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-64455-0 |