Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model

Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model

The mitochondrial permeability transition pore (mPTP) is a non-selective pore in the inner mitochondrial membrane (IMM) which causes depolarization when it opens under conditions of oxidative stress and high concentrations of Ca<sup>2+</sup>. In this study, a stochastic computational mod...

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Bibliographic Details
Main Authors: Keertana Yalamanchili, Nasrin Afzal, Liron Boyman, Carmen A. Mannella, W. Jonathan Lederer, M. Saleet Jafri
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Membranes
Subjects:
reactive oxygen species (ROS)
mitochondria
computational model
heart
mPTP
Monte Carlo method
Online Access:https://www.mdpi.com/2077-0375/12/5/494

Internet

https://www.mdpi.com/2077-0375/12/5/494

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