Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP). Unfortunately, the heteroresistance hampers polymyxin B monotherapy treatment via the amplification of resistant subpo...

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Bibliographic Details
Main Authors: Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Renxin Cai, Yang Lu, Liang Chen, Cha Chen, Bin Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
ceftazidime/avibactam
polymyxin B
heteroresistance
KPC-2-producing Klebsiella pneumoniae
bacterial killing activity
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02029/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.02029/full

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