Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration

Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration

Hepatocellular carcinoma (HCC) is the most common form of liver cancer worldwide. Increasing evidence suggests that mitochondria play a central role in malignant metabolic reprogramming in HCC, which may promote disease progression. To comprehensively evaluate the mitochondrial phenotype present in...

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Bibliographic Details
Main Authors: Kelsey L. McLaughlin, Margaret A.M. Nelson, Hannah S. Coalson, James T. Hagen, McLane M. Montgomery, Ashley R. Wooten, Tonya N. Zeczycki, Nasreen A. Vohra, Kelsey H. Fisher-Wellman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
metabolism
hepatocellular carcinoma
mitochondria
cancer
bioenergetics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.919880/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.919880/full

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