Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Abstract The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune tissue reconstitution remain a challenge for examining pathology in tissues. We uti...

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Bibliographic Details
Main Authors: Alex J. Holloway, Tais B. Saito, Kubra F. Naqvi, Matthew B. Huante, Xiuzhen Fan, Joshua G. Lisinicchia, Benjamin B. Gelman, Janice J. Endsley, Mark A. Endsley
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Retrovirology
Subjects:
HIV-1
Lymphoid tissue
Caspase − 1
Pathogenesis
Online Access:https://doi.org/10.1186/s12977-024-00641-2

Internet

https://doi.org/10.1186/s12977-024-00641-2

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