Poloxamer 188 Attenuates Ischemia-Reperfusion-Induced Lung Injury by Maintaining Cell Membrane Integrity and Inhibiting Multiple Signaling Pathways

Poloxamer 188 Attenuates Ischemia-Reperfusion-Induced Lung Injury by Maintaining Cell Membrane Integrity and Inhibiting Multiple Signaling Pathways

Background: Poloxamer 188 (P188) possesses anti-inflammatory properties and can help to maintain plasma membrane function. P188 has been reported to exert beneficial effects in the treatment of various disorders. However, the effects of P188 in ischemia/reperfusion (IR)-induced acute lung injury hav...

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Autors principals: Shih-En Tang, Wen-I Liao, Hsin-Ping Pao, Chin-Wang Hsu, Shu-Yu Wu, Kun-Lun Huang, Shi-Jye Chu
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2021-07-01
Col·lecció:Frontiers in Pharmacology
Matèries:
acute lung injury
ischemia-reperfusion
poloxamer 188
hypoxia/reoxygenation
membrane integrity
Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2021.650573/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.650573/full

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