Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

1H-benzimidazol-2-yl hydrazones with varying hydroxy and methoxy phenyl moieties were designed. Their effect on tubulin polymerization was evaluated in vitro on porcine tubulin. The compounds elongated the nucleation phase and slowed down the tubulin polymerization comparably to nocodazole. The poss...

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Bibliographic Details
Main Authors: Maria Argirova, Maya Guncheva, Georgi Momekov, Emiliya Cherneva, Rositsa Mihaylova, Miroslav Rangelov, Nadezhda Todorova, Petko Denev, Kameliya Anichina, Anelia Mavrova, Denitsa Yancheva
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
benzimidazole
anticancer
antioxidant
tubulin polymerization
molecular docking
drug-likeness
Online Access:https://www.mdpi.com/1420-3049/28/1/291

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https://www.mdpi.com/1420-3049/28/1/291

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