Dissecting Molecular Heterogeneity of Circulating Tumor Cells (CTCs) from Metastatic Breast Cancer Patients through Copy Number Aberration (CNA) and Single Nucleotide Variant (SNV) Single Cell Analysis

Dissecting Molecular Heterogeneity of Circulating Tumor Cells (CTCs) from Metastatic Breast Cancer Patients through Copy Number Aberration (CNA) and Single Nucleotide Variant (SNV) Single Cell Analysis

Circulating tumor cells’ (CTCs) heterogeneity contributes to counteract their introduction in clinical practice. Through single-cell sequencing we aim at exploring CTC heterogeneity in metastatic breast cancer (MBC) patients. Single CTCs were isolated using DEPArray NxT. After whole genome amplifica...

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Bibliographic Details
Main Authors: Tania Rossi, Davide Angeli, Michela Tebaldi, Pietro Fici, Elisabetta Rossi, Andrea Rocca, Michela Palleschi, Roberta Maltoni, Giovanni Martinelli, Francesco Fabbri, Giulia Gallerani
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
metastatic breast cancer
circulating tumor cells
copy number aberrations
single nucleotide variants
single cell sequencing
next generation sequencing
Online Access:https://www.mdpi.com/2072-6694/14/16/3925

Internet

https://www.mdpi.com/2072-6694/14/16/3925

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