P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress

P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress

Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired acute kidney injury. Cellular senescence is associated with CI-AKI. P16INK4a (p16) is a cell cycle regulator and link to aging and senescence. We found that the expression of p16 was elevated in CI-AKI rena...

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Bibliographic Details
Main Authors: Xiaodong Zhang, Guangyi Huang, Zhixuan Zhang, Fen Wang, Qian Liu, Yingqiang Du, Xiaoyan Wang, Xin Gu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Experimental Gerontology
Subjects:
p16INK4a
Contrast-induced acute kidney injury
Renal cell apoptosis
Inflammatory
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556524000147

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http://www.sciencedirect.com/science/article/pii/S0531556524000147

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