Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

IntroductionRestoration of immune tolerance may halt progression of autoimmune diseases. Tolerogenic dendritic cells (tolDC) inhibit antigen-specific proinflammatory T-cells, generate antigen-specific regulatory T-cells and promote IL-10 production in-vitro, providing an appealing immunotherapy to i...

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Bibliographic Details
Main Authors: Tatjana Nikolic, Jessica S. Suwandi, Joris Wesselius, Sandra Laban, Antoinette M. Joosten, Petra Sonneveld, Dick Mul, Henk-Jan Aanstoot, John S. Kaddis, Jaap Jan Zwaginga, Bart O. Roep
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
islet autoimmunity
clinical trial
immune intervention therapy
immunotherapy
tolerance induction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054968/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054968/full

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