(L)-Monomethyl Tyrosine (Mmt): New Synthetic Strategy via Bulky ‘Forced-Traceless’ Regioselective Pd-Catalyzed C(sp<sup>2</sup>)–H Activation

(L)-Monomethyl Tyrosine (Mmt): New Synthetic Strategy via Bulky ‘Forced-Traceless’ Regioselective Pd-Catalyzed C(sp<sup>2</sup>)–H Activation

The enormous influence in terms of bioactivity, affinity, and selectivity represented by the replacement of (L)-2,6-dimethyl tyrosine (Dmt) instead of Phenylalanine (Phe) into Nociceptin/orphanin (N/OFQ) neuropeptide analogues has been well documented in the literature. More recently, the non-natura...

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Bibliographic Details
Main Authors: Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Remo Guerrini, Valentina Albanese, Chiara Sturaro, Simona Stragapede, Davide Malfacini, Greta Compagnin, Martina Catani, Anna Fantinati
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
monomethyltyrosine
dimethyltyrosine
catalysis
peptides
Online Access:https://www.mdpi.com/1424-8247/16/11/1592

Internet

https://www.mdpi.com/1424-8247/16/11/1592

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