Auxotrophic <i>Lactobacillus</i> Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice

Auxotrophic <i>Lactobacillus</i> Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice

Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking PoRV infections. However, the difficulty in knock...

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Bibliographic Details
Main Authors: Hailin Zhang, Haiyuan Zhao, Yuliang Zhao, Ling Sui, Fengsai Li, Huijun Zhang, Jiaxuan Li, Yanping Jiang, Wen Cui, Guojie Ding, Han Zhou, Li Wang, Xinyuan Qiao, Lijie Tang, Xiaona Wang, Yijing Li
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Vaccines
Subjects:
<i>Lactobacillus</i>
CRISPR/Cas9D10A
nutritional deficient
porcine rotaviruses
oral immunization
Online Access:https://www.mdpi.com/2076-393X/10/9/1510

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https://www.mdpi.com/2076-393X/10/9/1510

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