Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis

Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis

Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63 osteosarcoma cell growth (p ≤ 0.001). IGF-I was shown to increase biglycan ex...

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Bibliographic Details
Main Authors: John Aggelidakis, Aikaterini Berdiaki, Dragana Nikitovic, Antonis Papoutsidakis, Dionysios J. Papachristou, Aristidis M. Tsatsakis, George N. Tzanakakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma growth
biglycan
small leucine rich proteoglycans
IGF-IR
β-catenin
extracellular matrix
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00470/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00470/full

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