Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice

Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice

Infection with Orientia tsutsugamushi, an obligate intracellular bacterium, can cause mild or severe scrub typhus. Some patients develop acute lung injury, multi-organ failure, and fatal infection; however, little is known regarding key immune mediators that mediate infection control or disease path...

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Bibliographic Details
Main Authors: Yuejin Liang, James Fisher, Casey Gonzales, Brandon Trent, Galen Card, Jiaren Sun, Alexei V. Tumanov, Lynn Soong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
Orientia tsutsugamushi
TNF
T cells
TNFR1
TNFR2
CD8
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.867924/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.867924/full

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