Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activity of TEAD (transcriptional enhanced associate doma...

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Bibliographic Details
Main Authors: Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D’Arca, Maria Paola Costi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
TEAD transcription factor
leads repurposing
luciferase assay
chemoinformatic
p-quinoid derivatives
Online Access:https://www.mdpi.com/1999-4923/14/2/391

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https://www.mdpi.com/1999-4923/14/2/391

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