Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation
<p>Abstract</p> <p>Background</p> <p>As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and activation of the membran...
| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
BMC
2012-07-01
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| Schriftenreihe: | BMC Immunology |
| Schlagworte: | |
| Online Zugang: | http://www.biomedcentral.com/1471-2172/13/40 |