Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation
<p>Abstract</p> <p>Background</p> <p>As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and activation of the membran...
| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
BMC
2012-07-01
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| シリーズ: | BMC Immunology |
| 主題: | |
| オンライン･アクセス: | http://www.biomedcentral.com/1471-2172/13/40 |