Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma

Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma

Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy. Nevertheless, the recurrence of MCC post-immunotherapy emphasizes the pressing need for more effective treatments. Recent research has highlig...

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Bibliographic Details
Main Authors: Jung Hyun Lee, Justin Daho Lee, Kelly Paulson, Valentin Voillet, Andre Berndt, Candice Church, Kristina Lachance, Song Y. Park, Naomi K. Yamamoto, Elizabeth A. Cromwell, Raphael Gottardo, Aude G. Chapuis, Paul Nghiem
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
CDK4/6 inhibitor
Hypoxia
Immunogenic cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023107298

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http://www.sciencedirect.com/science/article/pii/S2405844023107298

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