A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies

A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies

Enhancing production of protein cargoes delivered by gene therapies can improve efficacy by reducing the amount of vector or simply increasing transgene expression levels. We explored the utility of a 126-amino acid collagen domain (CD) derived from the C1qTNF3 protein as a fusion partner to chapero...

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Bibliographic Details
Main Authors: Brenda D. Moore, Yong Ran, Marshall S. Goodwin, Kavitha Komatineni, Karen N. McFarland, Kristy Dillon, Caleb Charles, Danny Ryu, Xuefei Liu, Stefan Prokop, Benoit I. Giasson, Todd E. Golde, Yona Levites
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
collagen domain
C1qTNF3
scFv
amyloid-β
immunotherapy
adeno-associated viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001857

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http://www.sciencedirect.com/science/article/pii/S2329050123001857

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