Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of transcription (STAT) proteins, SH2 domain interactions are critical for molecular activation and nuclear accumulation o...

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Bibliographic Details
Main Authors: Elvin D. de Araujo, Anna Orlova, Heidi A. Neubauer, Dávid Bajusz, Hyuk-Soo Seo, Sirano Dhe-Paganon, György M. Keserű, Richard Moriggl, Patrick T. Gunning
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
stat3
stat5
sh2 domain
mutations
cancer
autosomal-dominant hyper ige syndrome
inflammatory hepatocellular adenomas
t-cell large granular lymphocytic leukemia
t-cell prolymphocytic leukemia
growth hormone insensitivity syndrome
Online Access:https://www.mdpi.com/2072-6694/11/11/1757

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https://www.mdpi.com/2072-6694/11/11/1757

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