Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative

Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative

Abstract Mice have been increasingly used as preclinical model to elucidate mechanisms and test therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc (IVD) histological scoring systems have been proposed, but none exists that reliably quantitate mouse disc pat...

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Bibliographic Details
Main Authors: Itzel Paola Melgoza, Srish S. Chenna, Steven Tessier, Yejia Zhang, Simon Y. Tang, Takashi Ohnishi, Emanuel José Novais, Geoffrey J. Kerr, Sarthak Mohanty, Vivian Tam, Wilson C. W. Chan, Chao‐Ming Zhou, Ying Zhang, Victor Y. Leung, Angela K. Brice, Cheryle A. Séguin, Danny Chan, Nam Vo, Makarand V. Risbud, Chitra L. Dahia
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:JOR Spine
Subjects:
aging
degeneration
pre‐clinical models
structure‐function relationships
Online Access:https://doi.org/10.1002/jsp2.1164

Internet

https://doi.org/10.1002/jsp2.1164

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