Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients

Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients

Abstract Background Cachexia‐associated skeletal muscle wasting or ‘sarcopenia’ is highly prevalent in ovarian cancer and contributes to poor outcome. Drivers of cachexia‐associated sarcopenia in ovarian cancer remain elusive, underscoring the need for novel and better models to identify tumour fact...

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Bibliographic Details
Main Authors: Jorne Ubachs, Wouter R.P.H. van deWorp, Rianne D.W. Vaes, Kenneth Pasmans, Ramon C. Langen, Ruth C.R. Meex, Annemarie A.J.H.M. vanBijnen, Sandrina Lambrechts, Toon Van Gorp, Roy F.P.M. Kruitwagen, Steven W.M. Olde Damink, Sander S. Rensen
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Protein synthesis
Protein breakdown
Atrogenes
NF‐κB
Interleukin‐6
C2C12 cells
Online Access:https://doi.org/10.1002/jcsm.12885

Internet

https://doi.org/10.1002/jcsm.12885

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