Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.

Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13.5 due to severe hemorrhage. Here, conditional del...

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Bibliographic Details
Main Authors: Raymond F Robledo, Steven L Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, Luanne L Peters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008857

Internet

https://doi.org/10.1371/journal.pgen.1008857

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