Activation of α7 nicotinic acetylcholine receptor decreases on-site mortality in crush syndrome through insulin signaling-Na/K-ATPase pathway

Activation of α7 nicotinic acetylcholine receptor decreases on-site mortality in crush syndrome through insulin signaling-Na/K-ATPase pathway

On-site mortality in crush syndrome remains high due to lack of effective drugs based on definite diagnosis. Anisodamine is widely used in China for treatment of shock, and activation of α7 nicotinic acetylcholine receptor (α7nAChR) mediates such antishock effect. The present work was designed to te...

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Bibliographic Details
Main Authors: Bo-Shi eFan, En-Hui eZhang, Miao eWu, Jin-Min eGuo, Ding-Feng eSu, Liu eXia, Jian-Guang eYu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Crush Syndrome
Hyperkalemia
Mortality
insulin sensitivity
α7 nicotinic acetylcholine receptor
Na/K-ATPase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00079/full

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