Bortezomib-Induced Epigenetic Alterations in Nerve Cells: Focus on the Mechanisms Contributing to the Peripheral Neuropathy Development

Bortezomib-Induced Epigenetic Alterations in Nerve Cells: Focus on the Mechanisms Contributing to the Peripheral Neuropathy Development

Bortezomib-induced peripheral neuropathy (BiPN) occurs in approximately 40% of patients with multiple myeloma. The induction of severe neuropathy entails the dose reduction or complete elimination of bortezomib (BTZ). Interestingly, discontinuation of BTZ mostly results in a reduction or complete re...

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Bibliographic Details
Main Authors: Karolina Łuczkowska, Dorota Rogińska, Piotr Kulig, Anna Bielikowicz, Bartłomiej Baumert, Bogusław Machaliński
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
bortezomib-induced peripheral neuropathy
multiple myeloma
bortezomib
dLUHMES
Online Access:https://www.mdpi.com/1422-0067/23/5/2431

Internet

https://www.mdpi.com/1422-0067/23/5/2431

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