A Shared Pathogenic Mechanism for Valproic Acid and <i>SHROOM3</i> Knockout in a Brain Organoid Model of Neural Tube Defects

A Shared Pathogenic Mechanism for Valproic Acid and <i>SHROOM3</i> Knockout in a Brain Organoid Model of Neural Tube Defects

Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete closure of the neural tube. These conditions lead to either universal death (anencephaly) or severe lifelong complications (spina bifida). Despite hundred...

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Bibliographic Details
Main Authors: Taylor N. Takla, Jinghui Luo, Roksolana Sudyk, Joy Huang, John Clayton Walker, Neeta L. Vora, Jonathan Z. Sexton, Jack M. Parent, Andrew M. Tidball
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
neuroteratogen
anencephaly
induced pluripotent stem cells
Online Access:https://www.mdpi.com/2073-4409/12/13/1697

Internet

https://www.mdpi.com/2073-4409/12/13/1697

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