Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

Down syndrome (DS), or trisomy 21, is manifested in a variety of anatomical and cellular abnormalities resulting in intellectual deficits and early onset of Alzheimer’s disease (AD) with no effective treatments available to alleviate the pathologies associated with the disorder. The therapeutic pote...

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Bibliographic Details
Main Authors: Natalie Baker Campbell, Yesha Patel, Tara L. Moore, Maria Medalla, Ella Zeldich
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Down syndrome
Alzheimer’s disease
brain organoids
extracellular vesicles
mesenchymal stem cells
trisomy
Online Access:https://www.mdpi.com/1422-0067/24/4/3477

Internet

https://www.mdpi.com/1422-0067/24/4/3477

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