Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits. APP is cleaved by beta- and alpha-secretases to generate APP carboxy-terminal fragments (CTFs). Abeta peptide and a...

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Príomhchruthaitheoirí: Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Séverine Bégard, Hervé Drobecq, Antoine Ghestem, Marie-Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buée, André Delacourte, Nicolas Sergeant
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2005-11-01
Sraith:Neurobiology of Disease
Ábhair:
Amyloid precursor protein
Gamma-secretase
Phosphorylation
Proteomic
Alzheimer's disease
Presenilin
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S0969996105001439

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http://www.sciencedirect.com/science/article/pii/S0969996105001439

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