Pharmacology-based molecular docking of 4-methylcatechol and its role in RANKL-mediated ROS/Keap1/Nrf2 signalling axis and osteoclastogenesis

Pharmacology-based molecular docking of 4-methylcatechol and its role in RANKL-mediated ROS/Keap1/Nrf2 signalling axis and osteoclastogenesis

4-Methylcatechol (4-MC) is an agonist of various neurotrophic factors, which can upregulate the expression of Heme oxygenase 1 (HO-1) protein by activating nuclear factor erythroid 2-related factor 2 (Nrf2), thereby inhibiting oxidative stress-induced neural stem cell death. During RANKL-stimulated...

Full description

Bibliographic Details
Main Authors: Yang Xu, Dezhi Song, Yuangang Su, Junchun Chen, Liwei Wu, Haoyu Lian, Na Hai, Jing li, Jie Jiang, Jinmin Zhao, Jiake Xu, Qian Liu
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
4-Methylcatechol
Nrf2
Keap1
Osteoclast
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014901

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222014901

Similar Items