Purification and Biochemical Characterization of Taxadiene Synthase from <i>Bacillus koreensis</i> and <i>Stenotrophomonas maltophilia</i>

Purification and Biochemical Characterization of Taxadiene Synthase from <i>Bacillus koreensis</i> and <i>Stenotrophomonas maltophilia</i>

Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possible that silencing the expression of TDS is the most...

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Bibliographic Details
Main Authors: Ashraf S. A. El-Sayed, Maher Fathalla, Ahmed A. Shindia, Amgad M. Rady, Ashraf F. El-Baz, Yara Morsy, Basel Sitohy, Mahmoud Sitohy
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Scientia Pharmaceutica
Subjects:
Taxol
taxadiene synthase
terpene cyclase
taxadiene
factorial design optimization
Online Access:https://www.mdpi.com/2218-0532/89/4/48

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https://www.mdpi.com/2218-0532/89/4/48

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