The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
The KRAS gene is often mutated at several hotspot codons in cancer, resulting in similar, yet distinct, functional impacts on the KRAS protein. Here, the authors examine the genetic interactions of the different KRAS mutations across multiple cancer types and discover that KRAS mutations have allele...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22125-z |