The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca<sup>2+</sup> Homeostasis at Mitochondria-Associated ER Membranes

The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca<sup>2+</sup> Homeostasis at Mitochondria-Associated ER Membranes

The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the adhesion GPCR family. Mutations in VLGR1 have been associated with the human Usher syndrome (USH), the most common form of inherited deaf-blindness as well as childhood absence epilepsy. VLGR1 was previously found...

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Bibliographic Details
Main Authors: Jacek Krzysko, Filip Maciag, Anna Mertens, Baran Enes Güler, Joshua Linnert, Karsten Boldt, Marius Ueffing, Kerstin Nagel-Wolfrum, Martin Heine, Uwe Wolfrum
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
adhesion GPCR
mitochondria-associated ER membranes (MAM)
mitochondria-endoplasmic reticulum contact sites (MERCS)
Ca<sup>2+</sup> transient at ER and mitochondria
Ca<sup>2+</sup> homeostasis
Online Access:https://www.mdpi.com/2073-4409/11/18/2790

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https://www.mdpi.com/2073-4409/11/18/2790

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