Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model

Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model

Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell behavior within tumors, as well as spatial and temporal heterogeneity in response to immunotherapy. Here w...

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Bibliographic Details
Main Authors: Doreen Lau, Fabien Garçon, Anita Chandra, Laura M. Lechermann, Luigi Aloj, Edwin R. Chilvers, Pippa G. Corrie, Klaus Okkenhaug, Ferdia A. Gallagher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
intravital imaging
adoptive T-cell therapy
immune checkpoint inhibitors
immunocompetent
melanoma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01514/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01514/full

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