Chromatin changes in dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation.

Chromatin changes in dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation.

Loss of Dicer, an enzyme critical for microRNA biogenesis, results in lethality due to a block in mouse embryonic stem cell (mES) differentiation. Using ChIP-Seq we found increased H3K9me2 at over 900 CpG islands in the Dicer(-/-)ES epigenome. Gene ontology analysis revealed that promoters of chroma...

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Bibliographic Details
Main Authors: Jayantha B Tennakoon, Hongran Wang, Cristian Coarfa, Austin J Cooney, Preethi H Gunaratne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767645?pdf=render

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http://europepmc.org/articles/PMC3767645?pdf=render

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