Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in liver can be experimentally dissociated from insulin...

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Bibliographic Details
Main Authors: Tony Jourdan, Sarah M. Nicoloro, Zhou Zhou, Yuefei Shen, Jie Liu, Nathan J. Coffey, Resat Cinar, Grzegorz Godlewski, Bin Gao, Myriam Aouadi, Michael P. Czech, George Kunos
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
CB1 receptors
Kupffer cells
Insulin resistance
Inflammation
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817305847

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http://www.sciencedirect.com/science/article/pii/S2212877817305847

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