MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, but identifying genes robustly regulated by MeCP2 has been difficult. By integrating multiple transcriptomics d...

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Bibliographic Details
Main Authors: Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y Zoghbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
growth differentiation factor 11
Methyl CpG Binding Protein 2
MECP2 duplication syndrome
GDF11
MeCP2
Online Access:https://elifesciences.org/articles/83806

Internet

https://elifesciences.org/articles/83806

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