Gut Microbiota-Mediated Pharmacokinetic Drug–Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans

Gut Microbiota-Mediated Pharmacokinetic Drug–Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans

Mycophenolic acid (MPA) and trimethoprim-sulfamethoxazole (TMP-SMX) are commonly prescribed together in certain groups of patients, including solid organ transplant recipients. However, little is known about the pharmacokinetic drug–drug interactions (DDIs) between these two medications. Therefore,...

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Bibliographic Details
Main Authors: Nahathai Dukaew, Patcharawadee Thongkumkoon, Nutnicha Sirikaew, Sivamoke Dissook, Wannachai Sakuludomkan, Siripong Tongjai, Parameth Thiennimitr, Mingkwan Na Takuathung, Juthipong Benjanuwattra, Prachya Kongthaweelert, Nut Koonrungsesomboon
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
mycophenolate mofetil
mycophenolic acid
trimethoprim-sulfamethoxazole
pharmacokinetics
drug–drug interaction
gut microbiota
Online Access:https://www.mdpi.com/1999-4923/15/6/1734

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https://www.mdpi.com/1999-4923/15/6/1734

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